Endocrine Abstracts

Background: Persons with assigned either male (AMAB) or female (AFAB) sex at birth might wish to obtain feminization or masculinization, respectively. To this purpose, hormonal treatment with sex hormones must be tailored to each subject. Several studies and the European Society of Endocrinology guidelines tried to identify the optimal hormonal treatment in both AMAB and AFAB subjects. However, the clinical management in the long term follow-up remains challenging. Many treatm...

Introduction: Male idiopathic infertility represents a therapeutic challenge for physicians, since a targeted aetiological treatment does not exist. Several hormonal and non-hormonal therapies have been proposed so far to increase pregnancy rates. Among hormonal therapies, exogenous follicle-stimulating hormone (FSH) administration shows the most convincing physiological rationale in the face of a clinical efficacy below expectations. Indeed, from evidences available in the li...

Background: Erectile dysfunction (ED) represents the most frequent sexual dysfunction. Among several possible ED aetiologies, vascular ED (vED) presents the greatest implications for global individual health, resulting an early hallmark of cardiovascular diseases. Indeed, vED was demonstrated associated with a 1.25 times greater risk of developing major cardiovascular diseases. Alongside cardiovascular aspect, the evaluation of patients health, measured by the comorbidities nu...

Objective: Environmental rhythmicity seems able to affect the hypothalamic-pituitary-gonadal axis in animals, but the extent of its influence in humans is still controversial. This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big data approach.Methods: An observational, retrospective, big data trial was carried out, including all testosterone, luteinizing hor...

Background: Many chemicals present within the environment, as well as natural and artificial components of our diet, have the potential to interfere with the physiological role of hormones, interfering with hormone biosynthesis, signalling or metabolism. In the last years AMH, a protein secreted by granulosa cells, has emerged as a reliable marker of ovarian reserve. It is largely accepted the influence of age and smoking on AMH serum levels, although a clear effect of environ...

Background: HIV-infection is associated to an increased prevalence of erectile dysfunction (ED). In HIV-infected men ED seems to be less related to serum Testosterone (T), depending from other factors.Aim: To investigate the role of different components (organic, relational, psychological) of erectile function by using validate questionnaires in HIV-infected men with normal serum T.Methodology: Prospective, cross-sectional, observa...

Introduction: Thyroid function is commonly impaired in β-thalassemic patients with an estimated prevalence of hypothyroidism of 9–11%. According to literature, iron overload is the main cause of tissue damage involving both thyroid and pituitary gland, thus leading to primary or secondary hypothyroidism respectively. However, thyroid morphology has been rarely investigated in adults. The aim of this study is to evaluate thyroid volume (TV) and thyroid morphology in &...

Background: Environmental rhythmicity seems able to affect the hypothalamic-pituitary-gonadal axis in animals to achieve reproductive advantages. However, conflicting results were obtained when assessing the environmental-dependent rhythmicity on reproductive hormone secretion in humans.Aim of the study: This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big d...

Background: Ovarian and adrenal aging leads to a progressive decline in androgens levels and deleterious effects on the quality of life. Despite this, specific hormone replacement is not routinely recommended in the management of women with a physiological or pathological decline in their production, mainly due to the lack of long-term follow-up safety data.Aim of the study: To evaluate and summarize the existing data about hormonal profile changes in me...

Introduction: The management of craniopharyngioma (CR) remains a challenge. The introduction of endoscopic technique in the surgical approach to the sellar/suprasellar region would have profound implications for treatment. The aim of the study was to analyze results, advantages and limits of endoscopic endonasal approach (EEA).Design/methods: From 1998 to 2012, 95 patients underwent surgery for CR. Trancranial approach was chosen for 33 patients (35%) on...